His friends and colleagues threw the party at Club Guvnor on Saturday night.
Chameleone while addressing his guests, looked back at his illustrious life and career.
He attributed his massive success in the music industry to hard work and self-instruction.
“You may ask how I did it…Girls always have their aunties to give them advice but we the boys have to tussle it out on our own,” he said.
Heartbreaker
The Leone Island maestro also made a veiled reference to his estranged wife Daniella Atim, admitting to being a “troublemaker” sometimes.
“I am a trouble maker and a peacemaker. I am love maker and a heart breaker…I am a cocktail,” he said.
Chameleone remains separated with his wife of five, who left him and sought asylum in the United States 5 years ago.
Mrs Atim claimed enduring years of domestic abuse from the singer.
Meanwhile, Chameleone said this will be his last birthday party until he turns 50 in 2029.
He also revealed that he was hesitant to making this year’s birthday, having recently lost his brother Humphrey Mayanja, but that he was pushed by his friends